在附录腺癌中ctDNA的风景
Michael G White1, Mohammad A Zeineddine2, Eleanor A Fallon3
1Department of Colon and Rectal Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
概括
尾腺癌是一种罕见的癌症,与结直肠癌相比,尾腺癌的循环瘤DNA (ctDNA) 更少. 然而,ctDNA分析在临床上是有用的,用于识别可操作的突变,并预测这些患者的生存率.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
- 基因组学就是基因组学.
背景情况:
- 尾腺癌是一种罕见的癌症,对其分子病变的理解有限.
- 尾腺癌的转移通常涉及腹膜.
研究的目的:
- 用循环瘤DNA (ctDNA) 和组织测序分析尾腺癌的分子景观.
- 评估ctDNA分析在尾腺癌中的临床实用性.
主要方法:
- 分析了Guardant Health数据库中718名尾癌患者的分子数据.
- 对168名附腺癌患者进行了ctDNA分析,其中包括57名组织分析的回顾性审查.
- 临床病理和结果数据提取.
主要成果:
- ctDNA突变格局与组织测序不同,TP53是最常见的突变 (46%).
- 尾腺癌的ctDNA泄露频率低于结直肠癌 (38%比较高),变异性等位基因的频率较低.
- 可检测的ctDNA与高度组织学,额外皮质转移,TP53突变和更差的整体存活率有关.
- 在守护健康队列中的13.0%的患者中发现了可操作的突变.
结论:
- 尽管与结直肠癌相比,ctDNA分泌率较低,但ctDNA分析在尾腺癌中具有临床实用性.
- 在这种罕见的恶性瘤中,ctDNA分析可以帮助识别治疗点和预后标志物.
相关概念视频
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...


