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Updated: Jun 5, 2025

Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip
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Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip

Published on: September 27, 2019

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使用决定性单细胞组合反应堆的多个单细胞的高效组合.

Mina Yoshida1, Saori Tago1, Kunihiko Iizuka1,2

  • 1Institute of Industrial Science, University of Tokyo, Tokyo, Japan. shkim@iis.u-tokyo.ac.jp.

Lab on a chip
|December 16, 2024
PubMed
概括

这项研究引入了一种新型的微流体装置,可以有效地结合多个单细胞,这对于先进的生物研究,如单细胞分析至关重要. 确定性单细胞组合反应器 (DSCR) 装置实现了对多个细胞群的高配对和组合效率.

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相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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