长期鼻炎与鼻多元体的组织乙氨基基细胞的波动
Kunjira Sombutpiboonphon1, Kornkiat Snidvongs2,3, Saranath Lawpoolsri4
1Center of Excellence in Otolaryngology-Head & Neck Surgery, Rajavithi Hospital, Bangkok, Thailand.
International forum of allergy & rhinology
|December 16, 2024
概括
在慢性鼻炎与鼻息肉 (CRSwNP) 中,组织乙氨基酸细胞数 (TEC) 在六个月内保持稳定. 这一发现支持使用单次活检可靠诊断和管理2型CRSwNP.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 组织乙蛋白细胞计数 (TEC) 对于诊断2型慢性鼻炎与鼻息肉 (CRSwNP) 至关重要.
- 目前的做法依赖于通过多活检进行单个TEC评估.
- 对于CRSwNP诊断,TEC的时间稳定性以前没有得到评估.
研究的目的:
- 在患有CRSwNP的患者中,在6个月的时间内调查组织乙氨基酸细胞计数 (TEC) 的波动.
- 评估单个TEC测量的临床使用可靠性.
主要方法:
- 预期招募成年CRSwNP患者,不包括在4周内使用类固醇的人.
- 在基线,3个月和6个月时对多细胞活检的TEC评估.
- 同时评估SNOT-22,隆德-肯尼迪内镜评分 (LKES) 和血液中乙酸细胞水平.
主要成果:
- 在三个时间点中,没有观察到TEC,血中乙氨基酸计数/百分比,SNOT-22或LKES的统计学上显著差异.
- 在不同时间点,TEC与血液中乙氨基酸的数量和百分比有显著的相关性.
- 在6个月的研究持续时间内,TEC值的中位数显示出最小的变化.
结论:
- 在CRSwNP患者中,在6个月的时间内,组织乙酸细胞计数 (TEC) 稳定.
- TEC的稳定性支持单个活检用于临床评估的可靠性.
- 结果验证了从单个活检中使用TEC来管理CRSwNP.
相关概念视频
01:23Chronic Pharyngitis
1.1K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
1.1K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K