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Updated: May 15, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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人类乳头瘤病毒循环无细胞DNA动力学在宫癌患者接受绝对化学辐射的患者

Aaron Seo1, Weihong Xiao2, Olsi Gjyshi1

  • 1Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Clinical cancer research : an official journal of the American Association for Cancer Research
|December 16, 2024
PubMed
概括

在化疗 (chemoRT) 期间监测人类乳头瘤病毒 (HPV) 无细胞DNA (cfDNA) 可以预测宫癌无复发生存率 (RFS). HPV cfDNA 清除是 RFS 的一个强有力的预测因素,特别是当与成像结合时.

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Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...