歪曲的X染色体不活化作为对性对抗性选择的反应
Naomi L Greenberg1, Manus M Patten1
1Department of Biology, Georgetown University, 37th and O Streets NW, Washington DC.
Journal of evolutionary biology
|December 16, 2024
概括
性对抗可能会导致哺乳动物的X染色体失活. 遗传变异可以使一个X染色体逃脱不活化,从而影响遗传模式.
科学领域:
- 遗传学 是一个遗传学.
- 进化生物学 进化生物学
- 发育生物学 发展生物学
背景情况:
- 在雌性eutherians中,X染色体不活化使每个细胞中的一个X染色体沉默.
- 这一过程通常会导致母亲和父亲X染色体的平衡表达.
- 歪曲的X染色体失活,其中一个X被优先失活,可以由于遗传倾向而发生.
研究的目的:
- 调查性对抗性选择是否可以维持偏斜的X染色体失活的遗传变异.
- 模拟影响X染色体无活化选择的基因修饰剂的传播.
主要方法:
- 利用种群遗传模型来模拟进化动态.
- 分析了与性对抗基因相关的中性修饰剂的传播.
- 评估了人口大小对选择力 (漂移障碍) 的影响.
主要成果:
- 一个影响X染色体失活的中性修饰剂可以在与性对抗基因联系时传播.
- 传播动态类似于主导地位的修饰者.
- 性对抗可以促进歪曲的X染色体失活,但需要特定的有利条件.
结论:
- 性对抗性选择是一种潜在的进化机制,有利于倾斜的X染色体不活化.
- 影响取决于诸如联系和种群大小等因素.
- 这为理解X无活化模式的变化提供了一个框架.
更多相关视频
15:54Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
Published on: June 14, 2014
27.7K
05:31Author Spotlight: Whole-Mount Fluorescence In Situ Hybridization to Study Spermatogenesis in the Anopheles Mosquito
Published on: May 26, 2023
2.3K
相关概念视频
X-Inactivation
38.0K
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
38.0K
The Ratio of X Chromosome to Autosomes
8.4K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.4K
Dosage Compensation
6.1K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
6.1K
Inheritance of Chromatin Structures
6.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K
X and Y Chromosomes
22.0K
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
22.0K
X-linked Traits
53.4K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
53.4K
