在现实环境中比较药物持久性与口服和皮肤下注射的塞马格卢提德
Matteo Conti1,2, Lorenzo Pontiggia2, Michela Vergani2
1Department of Medicine and Rehabilitation, Policlinico di Monza, Monza, Italy.
Acta diabetologica
|December 16, 2024
概括
现实数据显示,与皮下注射相比,口服塞马格卢提德的药物持久性较低,胃肠道副作用是中止的主要原因. 在HbA1c和体重减轻方面的有效性在两个塞马格卢提德配方之间是相似的.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 糖尿病管理 糖尿病管理
背景情况:
- 塞马格卢提德是一种类似于葡萄糖的-1受体激动剂,用于治疗2型糖尿病 (T2DM).
- 在口服和皮下配方中可用,患者的坚持和有效性可能会有所不同.
- 现实世界的数据对于了解长期治疗结果至关重要.
研究的目的:
- 为了在现实环境中比较口服和皮下注射塞马格卢提德之间的药物持久性和疗效.
- 评估治疗延续率和临床结果的差异.
- 确定影响停止使用西马格卢提德配方的因素.
主要方法:
- 在单个中心进行回顾性观察性队列研究.
- 包括242名T2DM患者开始口服或皮下注射西马格卢提德.
- 主要终点:治疗持续时间在6,12和18个月;次要终点:HbA1c和体重的变化.
主要成果:
- 与皮下注射 (n=121) 相比,口服赛马格卢提德组 (n=121) 的持续率在6个 (85.3%对94.8%),12个 (72.3%对92.4%) 和18个月 (46.0%对83.8%) 的持续率较低.
- 胃肠道副作用是口服组中断药物的最常见原因.
- 调整后的分析显示,配方之间HbA1c或体重减轻没有显著差异.
结论:
- 与每周一次的皮下注射相比,口服赛马格卢提德的实际持久性明显较低.
- 通过HbA1c和体重变化来衡量疗效,可比于口服和皮下注射的塞马格卢提德.
- 胃肠道的耐受性可能会影响口服赛马格卢提德的坚持性.
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