扩大的周周血管空间 (EPVS) 与动脉瘤下关节出血 (aSAH) 后的功能和认知结果相关
Haichao Wang1, Qiuyue Yu2, Wenyi Zhang3
1Department of Neurology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Translational stroke research
|December 16, 2024
概括
在基底和半圆中心扩大的周围血管空间 (EPVS) 与动脉瘤下关节出血 (aSAH) 后更糟糕的结果有关. 虽然两种EPVS类型都预测了功能不良的结果,但只有中心半形EPVS与认知障碍有关.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 神经科学是一个神经科学.
背景情况:
- 动脉瘤破裂导致脑下关节出血 (SAH) 经常导致神经和认知缺陷.
- 扩大周血管空间 (EPVS) 对动脉瘤下关节出血 (aSAH) 后的结果的临床影响尚不清楚.
研究的目的:
- 调查EPVS严重程度和地形以及aSAH幸存者的临床结果之间的关联.
- 为了确定EPVS是否预测延迟脑缺血 (DCI),亚急性水脑,以及3个月的功能和认知状态.
主要方法:
- 从195名aSAH幸存者的MRI扫描进行了回顾性分析.
- 基于EPVS计数的临床特征的比较在基底 (BG) 和半骨中心 (CSO).
- 后勤回归用于评估EPVS与DCI,水头,功能结果 (mRS ≥3) 和认知功能 (MoCA) 的关联.
主要成果:
- 基底质中的EPVS (BG-EPVS ≥10) 与不利的功能结局,亚急性水头和DCI有关.
- 半骨中心的EPVS (CSO-EPVS) 与不利的功能结果和更差的认知功能有关.
- 在3个月后,在39.6%的患者中观察到认知障碍 (MoCA <22).
结论:
- 无论是BG-EPVS还是CSO-EPVS都独立地与aSAH后不良的功能结果有关.
- CSO-EPVS,但不是BG-EPVS,与ASAH后3个月的认知障碍有显著的相关性.
- 在MRI上的EPVS量化可能有助于预测aSAH患者的结果.
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