![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
用CAR T细胞疗法优化高风险复发/耐火 (r/r) DLBCL的现实世界结果:一则伏特卡斯特和案例例子
Gloria Iacoboni1, María Pérez Raya2
1Department of Hematology, University Hospital Vall d'Hebron, Barcelona, Spain. giacoboni@vhio.net.
Oncology and therapy
|December 16, 2024
概括
化学抗原受体 (CAR) T细胞疗法在治疗扩散性大B细胞淋巴瘤 (DLBCL) 中显示出有效性,即使是在高度病例中. 仔细管理诸如细胞因子释放综合征 (CRS) 和神经毒性等副作用对于患者的益处至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种侵略性的非霍奇金淋巴瘤.
- 复发性/耐药性 (r/r) DLBCL 存在重大治疗挑战.
- 化学抗原受体 (CAR) T细胞疗法已成为一个有前途的治疗方式.
研究的目的:
- 概述一个接受CAR T细胞治疗的患者对r/r DLBCL的管理.
- 描述CAR T细胞治疗在现实世界中的有效性.
- 要突出与CAR T细胞治疗相关的不良事件的管理.
主要方法:
- 一个病例研究详细介绍了患者与DLBCL的旅程,包括先前的治疗和进展.
- 使用tisagenlecleucel (一种CAR T细胞疗法).
- 对不良事件的监测和管理,包括细胞因子释放综合征 (CRS) 和免疫效应细胞相关的神经毒性综合征 (ICANS).
主要成果:
- 该患者在多次DLBCL治疗后接受了CAR T细胞疗法.
- 遇到和管理不良事件,包括CRS和ICANS.
- 现实世界的证据支持tisagenlecleucel在DLBCL中的有效性,与临床试验一致.
结论:
- 卡尔T细胞疗法可以在患有高风险r/rDLBCL的患者中获得持久的反应.
- 有效管理不良事件对于最大限度地提高治疗效益至关重要.
- 长期随访至关重要,以监测晚期不良事件和潜在的疾病复发.
相关概念视频
01:27Tumor Immunotherapy
475
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
475
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K