相关实验视频
Updated: Apr 13, 2026

13:09
Mass Spectrometric Analysis of Glycosphingolipid Antigens
Published on: April 16, 2013
16.5K
核磁共振成像揭示了水溶液中的多价值糖联物的动态聚合
Jian-Hong Tang1, Minrui Luo1, Wilhelmina Tsao1
1Departments of Chemistry, Molecular Biosciences, Neurobiology, and Radiology, Northwestern University, Evanston, Illinois 60208, United States.
Inorganic chemistry
|December 16, 2024
概括
研究人员开发了一种新的加多 (Gd(III)) 合物与银河糖. 这种分子在水中自我组装,为生物相容成像和诊断提供了新的可能性.
科学领域:
- 碳水化合物化学 碳水化合物化学
- 超分子化学 超分子化学
- 生物材料科学 生物材料科学
背景情况:
- 葡萄糖合物在哺乳动物细胞中至关重要,调解各种生物过程.
- 合成葡萄糖合物为像成像和药物输送等先进应用提供生物兼容平台.
- 由于结,糖的自我组装特性是它们有用性的关键.
研究的目的:
- 为了合成和表征一个多重体银河糖功能化的加多 (Gd(III)) 酸盐.
- 研究这种Gd(III) 复合物在水溶液中的自发动态聚合.
- 为了可视化多价值糖联物的in situ自我组装过程.
主要方法:
- 度依赖的磁共振 (MR) 放松测量.
- 核磁共振分散 (NMRD) 的分析.
- 动态光散射 (DLS) 用于水力动力半径的确定.
- 虚拟MRI成像用于实时可视化聚合.
主要成果:
- 在水的条件下,Gd(III) 复合体表现出自发的动态聚合.
- 在MR放松率和度 (0.03-1.35毫米) 之间观察到非线性关系.
- 在高度溶液中通过DLS检测到大的水力动力半径.
- 在现场MR成像成功可视化了实时动态自组装.
结论:
- 合成的Gd(III) 酸盐在水中表现出度依赖的动态聚合.
- 这种自我组装行为可以有效地使用MR放松和成像技术来监测.
- 这项研究提供了一种罕见的现场可视化多价值糖合物自我组装,有可能用于先进的成像和诊断应用.
相关概念视频
Protein Glycosylation
10.6K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Glycosylation occurs in...
10.6K
Oligosaccharide Assembly
3.9K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
3.9K
Proteoglycans
5.3K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
5.3K
Glycosaminoglycans
8.0K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
8.0K
Glycocalyx and its Functions
10.6K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
10.6K

