在14个国家的怀孕期间使用
Felix Wittström1, Carolyn E Cesta1, Brian T Bateman2
1Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
JAMA network open
|December 16, 2024
概括
怀孕期间的使用在过去二十年中在不同国家有很大差异. 许多妇女在怀孕期间停止了,并恢复了产后治疗,突出了对围产期精神病治疗的国际指导方针的需要.
科学领域:
- 围产阶段的精神病学
- 药物监督 药物监督 药物监督
- 生殖健康 生殖健康
背景情况:
- 对于预防精神病复发至关重要,但在怀孕期间会带来原性风险.
- 关于孕妇使用的信息有限.
研究的目的:
- 调查全球孕妇使用的流行率和模式.
- 分析围产期内处方的时间趋势和变化.
主要方法:
- 一项大规模的国际队列研究分析了14个国家的2000-2021年个体级妊娠数据.
- 使用的患病率估计使用处方数据在怀孕前,期间 (按三个月) 和怀孕后.
主要成果:
- 在不同的人群中,使用的患病率差异很大,在1000例怀孕中从0.07到1.56.
- 十个国家显示使用量增加,而一个国家下降,四个国家保持稳定.
- 怀孕三个月期间的使用量下降,产后使用量与怀孕前的水平相似,但在三个月使用量中观察到显著的国家特异性差异.
结论:
- 在孕妇使用方面存在重大的国际差异.
- 在怀孕期间停止治疗和产后重新开始治疗是一种常见的模式,因国家而异.
- 需要国际协调的指导方针来管理使用的孕妇的精神疾病.
相关概念视频
Mania and Antimanic Drugs: Overview
130
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
130
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
Factors Affecting Drug Response: Overview
1.8K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.8K
Drug Therapy
38
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
38
Antiepileptic Drugs: Potassium Channel Activators
143
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
143
Physiological Barriers
3.4K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
3.4K


