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通过单细胞测序,探索T细胞和NK细胞参与结性脊髓炎

Tianyou Chen1, Shengyu Ning1, Jichong Zhu1

  • 1The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.

Journal of cellular and molecular medicine
|December 16, 2024
PubMed
概括

这项研究使用单细胞测序揭示了结性脊髓炎 (AS) 中的关键免疫细胞相互作用. 在T细胞中的CD74和巨细胞迁移抑制因子信号传递在AS病变发生过程中至关重要.

关键词:
结性脊柱炎是一种疾病.细胞通信的细胞通信.免疫细胞是免疫细胞.免疫调节 免疫调节一个单细胞测序测序.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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