对二氧化和类似于二氧化的多化双的混合暴露与美国成年人肥胖之间的关联
Zhao-Xing Gao1,2, Peng Zhang1,2, Shu-Zhen Xu1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; Center for Big Data and Population Health of IHM, Hefei, Anhui, China.
The Journal of clinical endocrinology and metabolism
|December 16, 2024
概括
对二氧化和类似二氧化的多双 (DL-PCB) 的联合暴露与肥胖风险的增加有关. 糖化血红素A1c (HbA1c) 部分调解了这种关联,突出了干预的潜在途径.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 以前的研究表明,二氧化/DL-PCB与肥胖之间存在联系.
- 这些污染物对肥胖的综合影响尚不清楚.
研究的目的:
- 调查二氧化和DL-PCB的联合暴露与肥胖之间的关联.
- 探索糖化血红蛋白A1c (HbA1c) 在这种关系中的调解作用.
主要方法:
- 从NHANES (2003-2004) 分析了852名成年人的9种二氧化和DL-PCB.
- 应用通用线性回归,WQS回归和BKMR模型.
- 调解分析以评估HbA1c的作用.
主要成果:
- 二氧化物和DL-PCB被确定为肥胖风险因素.
- 联合暴露与肥胖有积极的相关性,其中1,2,3,4,6,7,8-hpcdd显著贡献.
- 在二氧化与肥胖之间的关联中,HbA1c占5.21%-9.04%.
结论:
- 对二氧化和DL-PCB的混合暴露与肥胖有关.
- HbA1c是在将二氧化碳暴露与肥胖联系起来的途径中是一个重要的调解者.
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