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调整主要成分可能会在全基因组关联研究中引发碰撞器偏差

Kelsey E Grinde1, Brian L Browning2, Alexander P Reiner3,4

  • 1Department of Mathematics, Statistics, and Computer Science, Macalester College, Saint Paul, Minnesota, United States of America.

PLoS genetics
|December 16, 2024
PubMed
概括

主要成分分析 (PCA) 可以在混合种群的全基因组关联研究 (GWAS) 中引入偏差. 仔细的数据预处理和诊断至关重要,以避免虚假的关联和偏见的结果.

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