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Updated: Jun 5, 2025

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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主要芳氨酸氨基的多种N-氧化,由工程P450过氧酶变体控制,由双功能小分子促进

Jie Chen1,2, Fuquan Yao1, Yiping Jiang1

  • 1Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao New Energy Shandong Laboratory, CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 16, 2024
PubMed
概括

研究人员使用双功能的小分子 (DFSM) 设计了细胞染色体P450BM3酶,以控制氨酸氧化. 这一突破使得从芳香胺中选择性生产有价值的含N的化合物成为可能.

关键词:
在N-氧化过程中.氨基胺是一种氨基胺.细胞染色体P450酶中的一种.酶催化酶的催化作用一个电子的氧化过程.

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