冷血脊椎动物利用行为发烧来缓解T细胞亡并优化抗菌免疫力
Haiyou Gao1, Xiumei Wei1, Kang Li1
1State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, Shanghai 200241, China.
概括
尼罗河鱼的行为发烧通过促进T细胞功能和减少亡来增强适应性免疫力. 这表明有发烧.
科学领域:
- 免疫学 免疫学 免疫学
- 动物行为 动物行为
- 进化生物学 进化生物学
背景情况:
- 发烧通过增强先天性和适应性免疫力,有利于内热体.
- 湿热动物使用行为温度调节,但其对适应性免疫力的影响尚不清楚.
- 目前尚不清楚,是否发烧适应性免疫协调是内热动物特有的,还是有着共同的脊椎动物特征.
研究的目的:
- 为了调查尼罗河鱼的行为发烧是否增强了适应性免疫力.
- 阐明发烧对冷血脊椎动物T细胞免疫力影响背后的机制.
主要方法:
- 在感染Edwardsiella piscicida的尼罗河鱼中诱导行为发烧.
- 分析T细胞激活,增殖,细胞因子生产 (IFN-γ),细胞毒性和亡.
- 调查HSP70,ERK1/2和caspase通路在发烧诱导的免疫调节中的作用.
主要成果:
- 行为发烧优化了T细胞免疫力感染后4-6天.
- 发烧增强了T细胞的IFN-γ和Granzyme B的产生,改善了细胞毒性.
- 发烧通过上调HSP70来缓解T细胞亡,该HSP70通过ERK1/2酸化抑制了caspase-8/caspase-3裂变.
结论:
- 尼罗河鱼的行为发烧优化了T细胞免疫力和对感染的生存能力.
- 发烧增强T细胞功能,并通过HSP70/ERK1/2通路减少细胞亡.
- 将发烧与适应性免疫结合在一起是一个古老的策略,早于四足动物.
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