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在2型糖尿病患者中评估血液的微循环和微神经学参数,使用生物光子技术
D A Umerenkov1, P B Ermolinskiy1, A E Lugovtsov1
1Department of Physics, Lomonosov Moscow State University, Moscow, Russia.
Journal of biophotonics
|December 16, 2024
概括
2型糖尿病通过增加红细胞 (RBC) 聚合和减少红细胞变形性来损害血液流动. 这些变化显著降低了毛细血管的血流速度,影响了微循环.
科学领域:
- 生物医学工程 生物医学工程
- 血液学 血液学 血液学
- 生理学 生理学 生理学
背景情况:
- 2型糖尿病 (T2DM) 与微血管并发症有关.
- 血液类风湿学变化与T2DM病变发生有关.
- 了解微循环变化对于管理T2DM至关重要.
研究的目的:
- 调查T2DM对血液微风学和微循环的影响.
- 量化T2DM患者红血细胞 (RBC) 聚合和变形能力的变化.
- 评估激光聚合计,光学子和数字毛细管显微镜在评估这些参数方面的实用性.
主要方法:
- 使用激光聚合计和光学笔进行体外测量.
- 在体内通过数字毛细管显微镜评估.
- 分析红细胞聚合率,水力动力强度和分解力.
主要成果:
- 与对照组相比,T2DM患者的红细胞聚合和总强度增加.
- 在T2DM中观察到红细胞变形性降低和全血粘度增加.
- 毛细血管血流速度显著下降与红细胞聚合增加相关.
结论:
- T2DM显著改变了血液微风学,其特点是红细胞聚合增强和变形性降低.
- 这些风湿变化导致T2DM中受损的微循环和减少的毛细血管血流速度.
- 使用的方法对评估T2DM中的微循环和微神经学变化是有效的.
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