神经精神疾病的保护学
Afeng Liu1, Lina Sun1, Wenshu Meng1
1School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.
Clinica chimica acta; international journal of clinical chemistry
|December 16, 2024
概括
蛋白质组学在神经精神疾病 (NDs) 中识别生物标志物方面表现有前途,尽管未得到充分利用. 为了开发准确的诊断和推进精准医学,需要进一步验证.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 神经精神疾病 (NDs) 的根本原因尚不清楚,导致可靠的诊断标记物稀缺.
- 蛋白质组学是生物标志物发现的关键技术,在ND研究中历史上一直未得到充分探索.
研究的目的:
- 审查基于质谱的蛋白质组学在神经精神疾病研究中的当前应用.
- 突出蛋白质组学在识别NDS早期诊断生物标志物的潜力.
主要方法:
- 本综述综合了利用基于质谱的蛋白质组学最近研究的发现.
- 对各种生物样本中蛋白质变化的分析,这些样本与NDs相关.
主要成果:
- 与NDs相关的蛋白质已在各种样本类型中确定,包括血液,尿液,唾液,眼,脑脊液和脑组织.
- 初步发现表明蛋白质组学可以识别NDs的潜在生物标志物.
结论:
- 蛋白质组学对开发神经精神疾病的新型客观生物标志物具有重大潜力.
- 大规模的多中心验证对于将这些蛋白质组发现转化为临床应用和推进NDs的精密医学至关重要.
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