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在公共卫生方面量化表观遗传衰老

Cynthia D J Kusters¹, Steve Horvath^2,3

¹Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA;

Annual review of public health

|December 16, 2024

概括

基于DNA甲基化的生物标记物或表观遗传钟显示出预防医学和健康监测的潜力. 本综述对这些时钟进行了调查,重点关注它们在不同人群和影响因素中的准确性.

科学领域:

生物医学科学生物医学科学
基因组学就是基因组学.
预防医学预防医学

背景情况:

生物年龄估计对于预防医学和健康监测至关重要.
基于DNA甲基化的生物标记物,称为表观遗传钟,是有前途的工具.
第二代表观遗传钟可以预测人类的发病率和死亡率.

研究的目的:

审查表观遗传时钟,特别是第二代时钟.
为了评估表观遗传时钟的有效性,考虑各种因素.
确定表观遗传钟研究当前的挑战和局限性.

主要方法:

关于表观遗传钟研究的文献综述.
专注于预测发病率和死亡率的第二代时钟.
分析影响时钟有效性的因素 (种族,性别,生活方式,环境).

主要成果:

表观遗传钟显示出有希望的结果,但需要进一步验证.
种族,性别,生活方式和环境等因素会影响时钟的准确性.
当前的研究面临着标准化和广泛应用方面的挑战.

结论:

表观遗传钟是评估生物年龄和健康的宝贵工具.
需要进一步的研究来完善它们的准确性,并解决影响因素.
解决这些局限性问题将提高它们在预防医学和人口健康方面的效用.

关键词:

老化的老化衰老的老化表观遗传年龄表观遗传年龄表观遗传时钟的时间表.人类研究研究人类研究.

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