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Updated: Jun 5, 2025

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在儿童患者中TGFB1基因的表达特征 患有隔离双动脉的儿科患者

Nazan Eras1, Ayşegül Çetinkaya2, Dilek Giray3

  • 1Department of Medical Genetics, Faculty of Medicine, Mersin University School of Medicine, Mersin University, 33343, Mersin, Turkey. nazaneras@gmail.com.

Pediatric cardiology
|December 16, 2024
PubMed
概括

这项研究发现,双主动脉 (BAV) 患儿的TGF-β1基因表达更高. 然而,在儿科BAV患者中,这种表达随着年龄的增长而下降,这表明需要进一步研究的潜在预后标志物.

关键词:
双主动脉门的双主动脉门基因表达 基因表达 基因表达标记器 标记器 标记器在BAV患者中TGF-β1预后标志物.

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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