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Updated: Jun 5, 2025

Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System
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Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System

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合理化mAb候选人选使用单一整体可开发性参数

Leon F Willis1,2, Isabelle Trayton3, Janet C Saunders3

  • 1School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.

Molecular pharmaceutics
|December 16, 2024
PubMed
概括

选择最小可开发性试验 (DAs) 有助于药物开发. 本研究确定了五个关键的DA,用于预测mAb稳定性,降低成本和提高可持续性.

关键词:
抗体是一种抗体.开发能力评估 开发能力评估这是一种配方配方.动力稳定性的动力稳定性蛋白质聚合蛋白质的聚合物

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Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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