整体/区域脂肪量与心脏代谢疾病的发展轨迹之间的各种关联:非线性多态模型
Xinming Xu1, Yi Guo2, Lili Huang1
1Department of Nutrition and Food Hygiene, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Institute of Nutrition, Clinical Research Unit, Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Obesity (Silver Spring, Md.)
|December 17, 2024
概括
身体脂肪分布影响心脏代谢疾病 (CMD) 的进展. 身体上部脂肪与死亡风险增加有关,而腿部脂肪可能会提供保护,挑战肥胖悖论.
科学领域:
- 代谢健康 代谢健康
- 肥胖问题研究研究
- 心血管流行病学心血管流行病学
背景情况:
- 心脏代谢性疾病 (CMD) 涵盖了一系列疾病,包括糖尿病,高血压和心脏病.
- 身体脂肪量 (FM) 和它的分布越来越被认为是代谢健康的关键因素.
- 了解特定脂肪储存和CMD轨迹之间的关系对于有针对性的干预至关重要.
研究的目的:
- 调查全身和区域脂肪量 (FM) 与心脏代谢疾病 (CMD) 的轨迹之间的关联.
- 为了检查不同的脂肪储存 (例如,腿,干,手臂) 如何影响CMD进展和死亡率的转变.
- 评估身体脂肪组成在与CMD相关的"肥胖悖论"的背景下发挥的作用.
主要方法:
- 来自423,966名参与者的英国生物库数据的前性分析.
- 脂肪质量指数 (FMI) 和区域FM (手臂,腿,干) 被用作暴露变量.
- 一个非线性多态框架模拟了FM和CMD轨迹之间的关联.
主要成果:
- 在整个/区域性FM和CMD轨迹过渡之间观察到各种各样的关联.
- 身体上部的FM (手臂,干) 显示了J形的关联与第一个CMD或多病性疾病的死亡率.
- 腿部 FM 显示了 L 形关联和在从第一个 CMD 到死亡的过渡中起着保护作用 (HR 0.950 / 1kg).
结论:
- 身体脂肪的组成和分布显著影响CMD轨迹.
- 身体上部脂肪积累与CMD或多病症患者的死亡风险增加有关,这反驳了肥胖悖论.
- 区域脂肪储存在心脏代谢健康和疾病进展中起着不同的作用.
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