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Updated: Jun 5, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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在BRCA1中瘤微环境和表观遗传调节与病原性变异相关的乳腺癌

Jun Yu Tay1, Josh Xingchong Ho1, Fan Foon Cheo2

  • 1Lee Kong Chian School of Medicine, Imperial College London-Nanyang Technological University, Singapore 308232, Singapore.

Cancers
|December 17, 2024
PubMed
概括

在BRCA1 (PVs) 的致病变体驱动激进的乳腺癌. 表观遗传调节剂LSD-1影响BRCA1/2表达和瘤生长,这表明LSD-1抑制剂是BRCA1/2PV相关乳腺癌的潜在治疗方法.

关键词:
在BRCA1和BRCA2病原性变异中,表观遗传学是指表观遗传学.遗传性乳腺癌是一种遗传性乳腺癌.氨酸特异性去甲基酶是什么瘤微环境是一个微环境.

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