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Updated: May 3, 2026

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根据NGS应用,揭开急性淋巴细胞白血病的遗传异质性

Valentina Ramírez Maldonado1, Josgrey Navas Acosta1, Iván Maldonado Marcos1

  • 1Centro de Investigación del Cáncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigación Biomédica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain.

Cancers
|December 17, 2024
PubMed
概括

下一代测序 (NGS) 通过揭示新的分子亚型,促进了对急性淋巴细胞白血病 (ALL) 的理解. 这种知识有助于个性化医疗,并改善了这种常见的儿童癌症的患者分层.

关键词:
急性淋巴细胞白血病急性淋巴细胞白血病下一代测序 (NGS) 是指下一代的测序.个性化医疗是个性化的医疗.进行全基因组测序.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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