多重同步T1乳腺癌的预后影响
Hongki Gwak1, Sung Hoo Jung2, Young Jin Suh3
1Division of Thyroid and Breast Surgical Oncology, Department of Surgery, Hwahong Hospital, Suwon 16630, Republic of Korea.
Cancers
|December 17, 2024
概括
有三个或更多同步的ipsilateral T1乳腺瘤与更糟糕的生存结果有关. 这一发现表明,对于多重T1瘤患者,需要加强治疗策略.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 手术瘤学手术瘤学
背景情况:
- 多种乳腺癌的发病率是高度可变的,受检测方法和定义的影响.
- 改进的成像技术提高了多种乳腺癌的检测.
- 多种乳腺癌的预后影响仍在争论中.
研究的目的:
- 调查同步ipsilateralT1乳腺瘤数量与存活率之间的关联.
- 基于瘤多重性的总生存率 (OS) 和乳腺癌特定生存率 (BCSS) 的比较.
主要方法:
- 对45881名经过手术的侵袭性乳腺癌患者 (2004-2016) 的回顾性分析.
- 根据瘤数目分组的患者:一个,两个或三个或更多同步的ipsilateral T1瘤.
- 这些组的OS和BCSS的比较.
主要成果:
- 一个和两个同步的ipsilateral T1瘤之间没有显著的生存差异.
- 患有三种或更多瘤的患者显示显著降低OS和BCSS.
- 多变量分析确定了三种或更多的瘤作为较差生存率的独立风险因素.
结论:
- 同步的双侧T1乳腺癌与三种或更多的瘤相关,预后更差.
- 这些患者可能会从升级治疗方法中受益.
- 对多重T1瘤量身定制的治疗策略进行进一步的研究是有必要的.
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