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Updated: May 5, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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蛋白质组分析确定了小鼠中5-甲诱导的肠粘膜炎的多种机制

Sergey M Ivanov1,2, Victor G Zgoda1, Valeria A Isakova3

  • 1Institute of Biomedical Chemistry, 119121 Moscow, Russia.

Cancers
|December 17, 2024
PubMed
概括

这项研究揭示了小鼠在5-甲 (5-FU) 诱导的肠道粘膜炎背后的分子机制. 了解这些途径,包括胰岛素信号传递,是制定预防这种常见化疗副作用的保护策略的关键.

关键词:
5 - - 甲酸是一种甲.抗瘤疗法是一种抗瘤治疗.生物信息学是一种生物信息学.蛋白质组学 蛋白质组学毒性的毒性 毒性的毒性

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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