使用口服避孕药的女性乳腺癌风险的全球区域比较-系统性审查和元分析
Agnieszka Drab1, Krystian Wdowiak1, Wiesław Kanadys2
1Department of Medical Informatics and Statistics, Medical University of Lublin, 20-059 Lublin, Poland.
口服避孕药 (OC) 的使用可能与乳腺癌 (BrCa) 风险增加有关,特别是在亚洲和中东. 这一全球元分析突出了与OC相关的BrCa风险的区域差异,强调了需要进一步研究的必要性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 乳腺癌 (BrCa) 发病率在全球范围内不断上升,特别是在发展中国家.
- BrCa风险的地理差异受风险因素,检测率,种族和临床特征的影响.
- 口服激素避孕药 (OCs) 被广泛使用,需要了解它们与BrCa.的潜在联系.
研究的目的:
- 系统地审查和对口服避孕药 (OC) 使用与乳腺癌 (BrCa) 风险之间的关联进行观察性研究进行元分析.
- 为了研究OC-BrCa风险关系的地理变异.
- 提供关于这个话题的当前证据的全面摘要.
主要方法:
- 74项观察性研究的系统综述和元分析.
- 纳入标准:调查OC使用和BrCa风险的研究,共198579名女性.
- 相对风险 (RR) 用森林地块计算和呈现,根据地理区域进行子组分析.
主要成果:
- 整体元分析表明,与OC使用相关的BrCa风险可能会增加.
- 在亚洲 (RR = 1.29,p = 0.014) 和中东 (RR = 1.29,p = 0.043) 观察到统计学上显著的风险增加.
- 在非洲,美洲或欧洲国家没有发现具有统计意义的关联.
结论:
- 口服避孕药的使用可能与患乳腺癌的风险更高有关.
- 氧化使用与BrCa风险之间的关联因地理区域而异.
- 需要进一步的研究来阐明特定区域的风险因素和机制.
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