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生物标志物和病理反应在直肠癌的景观:我们站在哪里?

Abrahams Ocanto^1,2,3, Macarena Teja^1,2, Francesco Amorelli⁴

¹Department of Radiation Oncology, Hospital Universitario San Francisco de Asís, GenesisCare, 28002 Madrid, Spain.

|December 17, 2024

概括

总的新辅助疗法 (TNT) 与标准的新辅助疗法 (NAT) 相比,改善了结直肠癌 (CRC) 的病理完整反应 (pCR) 率. 识别预测生物标志物对于优化TNT患者选择和治疗策略至关重要.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

结肠直肠癌 (CRC) 是一种普遍存在的全球性瘤.
多模式治疗,包括化疗,放射治疗和手术,是局部高级阶段的标准.
总的新辅助疗法 (TNT) 与传统的新辅助疗法 (NAT) 相比,提高了病理完整反应 (pCR) 率.

研究的目的:

审查强大的预后生物标志物用于结直肠癌的临床实践.
评估各种生物标志物的优缺点.
强调生物标志物组合对治疗反应的预测价值.

主要方法:

关于结直肠癌中预后生物标志物的现有文献的综述.
对血液学,分子学和成像学标记物的分析.
综合生物标志物方法的评估.

主要成果:

与NAT (20-25%) 相比,TNT的pCR率更高 (高达37%).
目前的生物标志物显示出矛盾的结果,限制了常规临床使用.
生物标志物组合显示出改善预测价值的潜力.

结论:

需要进一步的研究来确定TNT的最佳患者群体.
强大的预后生物标志物及其组合对于预测疾病进程和指导CRC治疗至关重要.
在临床实践中使用生物标志物的标准化是必要的.

关键词:

生物标志物生物标志物这是直肠癌.总的新辅助疗法治疗.

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