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在胃癌患者接受新辅助化疗和手术后肠道微生物组的变化
Kristina Žukauskaitė1,2, Bernardas Baušys1,3, Angela Horvath2,4
1Institute of Biosciences, Life Science Center, Vilnius University, 01513 Vilnius, Lithuania.
Cancers
|December 17, 2024
概括
对于晚期胃癌的激进胃切除术显著改变了肠道微生物群,导致口服. 新辅助化疗的影响最小,手术是这些长期微生物组变化的主要驱动因素.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 在瘤学瘤学.
背景情况:
- 新辅助化疗 (NAC) 随后的激进胃切除术是高级胃癌 (GC) 的标准.
- 无论是NAC还是胃切除术都会影响肠道微生物群.
- 没有先前的纵向研究研究了这些在GC治疗过程中的变化.
研究的目的:
- 为了研究在新辅助化疗和GC的激进胃切除术期间肠道微生物群的纵向变化.
- 评估NAC和胃切除术对肠道微生物组合,多样性和肠道炎症和透性的标志物的影响.
主要方法:
- 对接受NAC和胃切除术的GC患者进行长度观察研究.
- 便微生物组组成,α/β多样性,便calprotectin和肠道透性标记 (LBP,sCD14) 在基线,NAC后和胃切除术后被分析.
主要成果:
- 在类层面上,NAC没有改变肠道微生物组的组成.
- 激进胃切除增加了Bacteroidetes和Proteobacteria,减少了Firmicutes和Actinobacteria,并显著影响了微生物群的多样性.
- 胃切除术导致了与口服相关的细菌的丰富 (例如, *Escherichia-Shigella*, Enterobacteriaceae). 肠道炎症和透性标志物保持不变.
结论:
- 晚期GC的激进治疗会导致肠道微生物组的长期变化,特别是口服.
- 根本性胃切除术,而不是NAC,是这些持续的微生物组变化的主要驱动因素.
- 准肠道微生物群口述可能会改善GC幸存者胃切除术后的生活质量.
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