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用 (化疗) 放射治疗治疗的头癌患者的营养性别差异:从前性试验的结果

Rouzbeh Zohri^1,2,3, Lorenz Hahn⁴, Niloufar Seyedi^5,6

¹Department of Osteology, Outpatient Center, University Medical Center Hamburg-Eppendorf, 22529 Hamburg, Germany.

|December 17, 2024

概括

这项研究揭示了头癌患者对化疗放射治疗的营养反应的显著性别差异. 针对性,性别特定的营养支持对于改善这些患者的治疗结果至关重要.

科学领域:

在瘤学瘤学.
营养科学营养科学
辐射疗法辐射疗法

背景情况:

接受化疗放射治疗 (CRT) 的头癌 (HNC) 患者经常遇到营养挑战.
对癌症治疗和营养状况的性别特异反应尚未完全理解.

研究的目的:

研究受CRT治疗的HNC患者的营养状况,体重变化及其对整体存活期 (OS) 的影响的性别特异性差异.
在HNC治疗期间根据性别确定影响生存的因素.

主要方法:

对61名HNC患者 (17名女性,44名男性) 进行治疗性CRT (2018-2020) 的前性研究.
综合营养评估:饮食问卷,人体测量 (BMI,身体组成的BIA) 和生物标志物 (白蛋白,CRP).
在治疗前,治疗期间和CRT后进行的评估.

主要成果:

在表现状态,热量摄入量,相角 (PA) 和无脂肪质量指数 (FFMI) 中观察到的基线性别差异.
与女性相比,男性在CRT期间表现出更大的卡路里赤字和BMI,FFMI和PA的减少.
男性的营养不良风险显著增加;女性的白蛋白下降更为明显.
生存分析显示,基线营养参数 (卡路里赤字,BMI,PA,FFMI) 预测了男性的生存,而治疗结束时的白蛋白预测了女性的生存.

结论:

在HNC患者中对CRT的独特性别特异的营养和生化反应.
基线相位角度是男性HNC患者生存的重要预测指标.
针对性,性别特定的营养干预措施对于优化接受CRT的HNC患者的治疗结果至关重要.

关键词:

营养不良营养不良营养不良生物电阻分析分析生物电阻分析没有脂肪的质量指数.阶段角是相位的角度.幸存率幸存率生存率

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