膀癌诊断和治疗中的性别差异
Géraldine Pignot1, Philippe Barthélémy2, Delphine Borchiellini3
1Department of Surgical Oncology 2, Institut Paoli-Calmettes, 13009 Marseille, France.
Cancers
|December 17, 2024
概括
男人患膀癌的风险较高,但女性面临较晚的诊断和晚期的癌症. 性差异影响治疗和结果,需要进一步的研究,以改善尿路细胞癌的管理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 性别医学性别医学
背景情况:
- 在癌症发病率,侵袭性,治疗反应和结果方面存在显著的性别差异.
- 膀癌在诊断,治疗和预后方面表现出明显的性别差异.
研究的目的:
- 总结了膀癌诊断和治疗中的性别差异.
- 根据性别和性别,确定改善膀癌管理的领域.
主要方法:
- 关于膀癌的性别差异现有文献的综述.
- 对膀癌不同阶段的诊断和治疗模式的分析.
- 评估与性别相关的临床结果和治疗反应.
主要成果:
- 男人患膀瘤的风险较高,但女性在晚期被诊断出来,通常是肌肉侵入性疾病.
- 在Bacillus Calmette-Guerin治疗后,女性的非肌肉侵入性膀癌 (NMIBC) 复发率更高,肌肉侵入性膀癌 (MIBC) 的治疗更少.
- 女性的预后较差,可能是由于性别特异性瘤生物学和对治疗的不同反应,以及临床试验中的代表性不足.
结论:
- 对性别和性别角色的紧急调查对于推进泌尿道癌管理至关重要.
- 解决诊断,治疗准入和临床试验参与方面的差异对于改善膀癌妇女的治疗结果至关重要.
- 了解与性别相关的因素可以优化治疗策略,特别是基于免疫的疗法.
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