患有局部,主发性头部和部共肉瘤的患者的瘤结果
Riddhi R Patel1,2, Vancheswaran Gopalakrishnan3, Behrang Amini4
1Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, |1515 Holcombe Blvd., Houston, TX 77030, USA.
Cancers
|December 17, 2024
概括
局部疾病的头突肉瘤 (HNSS) 患者有良好的预后. 术后放射治疗改善了局部控制,而化疗延迟了转移,特别是在4厘米以上的瘤中.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 头结膜肉瘤 (HNSS) 是一种罕见的恶性瘤.
- 评估局部HNSS的生存结果对于治疗计划至关重要.
研究的目的:
- 为了评估头部和部初级突肉瘤 (HNSS) 患者的生存结果,呈现局部疾病.
- 确定影响整体生存 (OS),局部无复发生存 (LRFS) 和无转移生存 (MFS) 的预后因素.
主要方法:
- 在1981年至2020年期间诊断的57名初级HNSS患者的回顾性图表审查.
- 卡普兰-梅尔法,日志等级测试和康克斯回归用于生存分析.
- 从诊断和初级瘤治疗完成后的OS,LRFS和MFS的估计.
主要成果:
- 五年OS,LRFS和MFS的比率分别为80.4%,67.7%和50.6%.
- 加上手术的放射治疗 (RT) 改善了LRFS (HR:0.03).
- 术后化学疗法与手术和RT改善了MFS (HR:0.10),特别是在4厘米以上的瘤 (5年MFS:53.2%对比20.0%).
结论:
- 头部和部突肉瘤 (HNSS) 在局部疾病中通常具有有利的预后.
- 在外科手术期间的RT增强了局部瘤控制.
- 术后化疗对于延缓HNSS转移至关重要,特别是对于较大的瘤 (≥4厘米),因此需要考虑全身治疗.
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