TXK和PLCE1基因的多态性及其与阿希丹雅克斯生长特征的相关性分析
Juanxiang Zhang1,2, Xita Zha3, Guowu Yang1,2
1Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou 730050, China.
Animals : an open access journal from MDPI
|December 17, 2024
概括
TXK和PLCE1基因中的单核酸多态性与阿希丹雅克的生长特征有关. 特定的基因型与增加的身体长度和胸围相关,有助于雅克的繁殖策略.
科学领域:
- 动物遗传学动物遗传学
- 分子生物学分子生物学
- 畜牧养殖 畜牧养殖 畜牧养殖
背景情况:
- 氨酸蛋白激酶 (TXK) 基因和脂酶Cepsilon 1 (PLCE1) 基因对信号转导和肌肉发育分别至关重要.
- 两种TXK和PLCE1基因都与牲畜中经济重要特征有关.
- 了解这些基因的遗传变异可以为改善动物生产的育种计划提供信息.
研究的目的:
- 调查TXK和PLCE1基因中的单核酸多态 (SNPs) 与Ashidan yaks的生长特征之间的关联.
- 为了识别潜在的分子标记物,以提高阿希丹山的繁殖.
- 分析特定SNP位点与体重,身高,长度和胸围的相关性.
主要方法:
- 使用cGPS液体微阵列对232只阿希丹雅克进行基因定型.
- 对两个SNP位点的分析:TXK中的g.55,999,531C>T和PLCE中的g.342,350T>G1.
- 在不同年龄段的SNP基因型和各种生长参数之间的统计相关性分析.
主要成果:
- 在TXK g.55,999,531C>T位点和生长特征之间发现了显著的相关性.
- 在PLCE1 g.342,350T>G位点和生长特征之间发现了显著的相关性.
- 特定的基因型 (例如,TXK中的CC,PLCE1中的GG) 与不同发育阶段的身体长度,胸围和身高显著增加有关.
结论:
- 在TXK和PLCE1基因中确定了SNP位点,作为阿希丹的生长特征的有价值的分子标记.
- 这些发现为阿希丹山繁殖计划中的标记辅助选择提供了理论支持.
- 准这些基因位置可以有助于选择性地改善阿希丹的生长性能.
相关概念视频
01:09Epistasis Analysis
4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K
01:39Epistasis
45.8K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
45.8K
01:33Pleiotropy
39.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
39.7K
01:18Polygenic Traits
64.7K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
64.7K
01:43Incomplete Dominance
21.4K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
21.4K
02:41Lethal Alleles
14.8K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
14.8K