肠道透性的生物标志物受到性结肠炎患者饮食的影响 - - 一项探索性研究
Natasha Haskey1,2, Maximillian Eisele1, Andreina Bruno3
1Department of Medicine, Cumming School of Medicine, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.
性结肠炎 (UC) 患者的脂多糖结合蛋白 (LBP) 水平与疾病活性和饮食摄入有关. 较高的LBP与较差的饮食质量和增加的疾病活性有关,这表明LBP是潜在的生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 肠上皮质屏障的破坏增加了肠道透性 (IP),导致慢性炎症.
- 西方饮食与IP的增加有关,而富含多的饮食则降低了它.
- 性结肠炎 (UC) 中的饮食,疾病活性和IP之间的相互作用需要进一步阐明.
研究的目的:
- 为了评估UC患者的血清佐努林和脂多糖结合蛋白 (LBP) 水平.
- 研究这些生物标志物,饮食因素和UC的疾病活性之间的关系.
主要方法:
- 对37名UC参与者的横截面分析.
- 通过ELISA测量血清LBP和zonulin.
- IP标记,饮食摄入量和疾病活性 (部分梅奥得分) 之间的相关性分析.
主要成果:
- 腰痛与疾病活性相关 (部分梅奥得分),总脂肪和精制谷物.
- 腰痛与水果消费和整体饮食质量有负相关性.
- 佐努林与蛋白质,氨酸和维生素B12有负相关性;观察到与BMI正相关性的趋势.
结论:
- 血清LBP水平与UC患者的疾病活性和饮食模式有关.
- 在UC中,LBP可以作为评估疾病活性和饮食质量的潜在生物标志物.
- 需要进一步的临床试验来验证这些发现.
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