人类细胞染色体P450与癌症相关的代谢活动和基因多态性:一篇综述
Innokenty M Mokhosoev1, Dmitry V Astakhov2, Alexander A Terentiev3
1Independent Researcher, 108815 Moscow, Russia.
Cells
|December 17, 2024
概括
细胞染色体P450 (CYP) 酶表现出多样化的代谢活动,影响癌症的发展和药物反应. 了解CYP功能和遗传变异对于个性化癌症疗法至关重要.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 细胞染色体P450 (CYPs) 是含血的基本氧化还原酶,具有广泛的单氧化酶活性.
- 人类CYP会代谢大量内源和外源化合物,包括药物,激素和致癌物.
研究的目的:
- 审查CYP异构体在生物激活和排毒中的双重作用的最新发现.
- 探索CYPs在激素敏感癌症和耐药性中的参与.
- 讨论CYP基因多态化对癌症和药物敏感性的影响.
主要方法:
- 关于CYP功能及其在癌症中的影响的最新数据的文献综述.
- 对CYP参与激素代谢和癌症发展 (乳腺,卵巢,子宫内膜,前列腺) 的分析.
- 检查CYP介导的药物代谢,药物相互作用,以及它们在抗癌药物耐药性中的作用.
主要成果:
- 基因组异型可以激活或解毒基质,导致不同的毒理结果,取决于反应类型,基质,组织和物种.
- 雌激素和雄激素的CYP介导代谢在激素敏感癌症中至关重要;特定的CYP活动有助于前列腺癌的进展.
- CYP基因多态性影响个体对癌症的易感性和药物疗效,影响代谢器表型.
结论:
- CYP的代谢多功能性和双重生物效应是它们在激素敏感癌症中的核心作用.
- 癌症和药物敏感性的个体间变异与CYP活性变异和遗传多态性有关.
- 代酶酶酶抑制剂是开发个性化抗癌疗法的有希望的途径.
更多相关视频
09:33Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
Published on: March 20, 2018
13.8K
10:44Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
9.8K
相关概念视频
Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
Electron Transport Chain: Complex I and II
11.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
11.3K
Factors Affecting Drug Biotransformation: Biological
107
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
107
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Drug Metabolism: Phase I Reactions
3.1K
A phase I reaction is a biochemical process that introduces a functionally reactive polar group to a substance. This transformation predominantly occurs in the liver, facilitated by the cytochrome P450 system of hemoproteins situated in the lipophilic endoplasmic reticulum of cells. The metabolite generated through this process can have varying polarities. If it is sufficiently polar, it can be easily excreted in the urine due to its water compatibility. However, if the metabolite is nonpolar,...
3.1K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
