来自Sacha Inchi餐的抗氧化:一种体外,活体和体的方法.
Erwin Torres-Sánchez1, Iván Lorca-Alonso2, Sandra González-de la Fuente2
1Facultad de Ciencias Agrarias, Universidad Nacional de Colombia Sede Bogotá, Carrera 30 No. 45-03, Bogotá 111321, Colombia.
Foods (Basel, Switzerland)
|December 17, 2024
概括
在模拟消化过程中,Sacha Inchi蛋白缩物 (SPC) 的抗氧化被释放出来. 这些具有功能性食品和药物输送的潜力,其中一些对自由基清除具有增强的生物可用性.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物化学 生物化学
- 生物信息学是一种生物信息学.
背景情况:
- 来自植物的抗氧化通过保护氧化,提供功能性食物潜力.
- 萨沙英奇油压蛋糕 (SIPC) 是用于生产萨沙英奇蛋白缩剂 (SPC) 的副产品.
研究的目的:
- 用综合方法评估SPC中的在消化过程中的释放和抗氧化潜力.
- 使用体外,体外和在的方法来表征抗氧化.
主要方法:
- 标准化静态INFOGEST 2.0协议用于SPC的体外水解.
- 在体外和体外测试 (ABTS,ORAC,巨细胞中的ROS降低) 来评估抗氧化活性.
- 生物信息学工具用于 de novo 体的确定,抗氧化的识别和生物可用性预测.
主要成果:
- 与SPC相比,SPC的胃和肠消化表现出增强的抗氧化活性 (ABTS,ORAC).
- 胃消化分量减少了巨细胞中的活性氧物种 (ROS),并逆转了LPS诱导的损伤.
- 确定了416种耐药,其中315种被预测为抗氧化剂;一些显示出细胞外标的潜力和改善生物可用性.
结论:
- 在胃肠道消化过程中,Sacha Inchi蛋白缩物 (SPC) 产生抗氧化.
- 这些具有功能性食品和治疗应用的潜力,需要进一步验证.
- 在 silico 预测表明特定的序列具有有前途的抗氧化剂和生物可用性特征,用于未来的开发.
相关概念视频
Oxidation-Reduction Reactions
Oxidation–Reduction Reactions
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids
Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.
Oxidation and Reduction of Organic Molecules
Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...
The removal of an electron from a molecule, results in a...
Oxidation of Phenols to Quinones
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
Radical Autoxidation
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...


