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在体外和体外研究评估单谷酸盐的安全性

Tania Merinas-Amo¹, Rocío Merinas-Amo¹, Ángeles Alonso-Moraga¹

¹Department of Genetics, University of Córdoba, 14071 Córdoba, Spain.

Foods (Basel, Switzerland)

|December 17, 2024

概括

单谷氨酸 (MSG) 在可接受的每日摄入量 (ADI) 水平下是安全的,在Drosophila中没有毒性或基因毒性. 它还显示了抗氧化应激的保护作用和潜在的抗瘤活性.

科学领域:

毒理学毒理学毒理学
营养保健品营养保健品
癌症研究癌症研究

背景情况:

对单谷氨酸 (MSG) 的有争议的研究需要进一步的安全评估.
动物和细胞模型对于理解MSG的生物效应至关重要.

研究的目的:

用Drosophila melanogaster模型评估MSG的安全性.
调查MSG的潜在营养药物和化学预防作用.

主要方法:

在多种度下,评估了多糖毒性,基因毒性,寿命和Drosophila的健康寿命.
评估了MSG对过氧化引起的损伤的保护作用.
研究了MSG对HL-60细胞系的细胞毒性和抗瘤活性.
分析了LINE1 DNA甲基化作为化学预防的标记.

主要成果:

在可接受的每日摄入量 (ADI) 度 (0.06 mg/mL) 的MSG中,没有对Drosophila的毒性或基因毒性,从而保持了寿命.
多糖对氧化应激有保护作用,抑制了43.7%的基因毒性,并增加了32%的健康寿命.
MSG对HL-60细胞表现出细胞毒性和抗瘤活性,诱导DNA碎片化和显著的LINE1DNA甲基化.

结论:

在ADI水平下,MSG是安全的消费,在Drosophila没有观察到毒性或基因毒性.
多糖表现出潜在的营养药物益处,包括抗氧化和抗原毒性.
作为一种化学预防剂,MSG显得有前途,其抗瘤活性和诱导癌细胞中的DNA甲基化表明了这一点.

关键词:

造成的DNA损伤是DNA损伤.这种植物是Drosophila melanogaster.它具有抗毒性和抗毒性.细胞毒性细胞毒性食品添加剂是一种食品添加剂.白血病的细胞是白血病的细胞.长寿长寿是一个问题.甲基化状态甲基化状态单谷氨酸盐的使用方法毒性的毒性毒性的毒性

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