检查超重,肥胖和刺激性肠综合征之间的关联:系统性审查和元分析
Chun En Yau1, Gwendolyn Shan Jing Lim1, Asher Yu Han Ang1
1NUS Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Nutrients
|December 17, 2024
概括
过重的体重与刺激性肠综合征 (IBS) 风险没有显著联系. 然而,在使用罗马IV诊断标准时,肥胖与IBS有显著的关联,这表明存在微妙的关系.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的肠-大脑相互作用障碍.
- 肥胖作为IBS风险因素的作用是有争议的,有相互矛盾的证据.
- 全球肥胖和IBS的增加需要澄清它们之间的关联.
研究的目的:
- 进行一个元分析,调查肥胖和IBS之间的关联.
- 评估增加的BMI是否与IBS的更高患病率相关.
主要方法:
- 搜索了Embase,MEDLINE和Cochrane图书馆的相关研究.
- 包括27项报告IBS患病率和BMI的几率比率的研究.
- 根据诊断标准进行随机效应元分析和灵敏度分析.
主要成果:
- 在超重/肥胖的BMI和IBS之间没有发现显著的关联 (分别为OR 1.02和1.11).
- 肥胖BMI和IBS之间出现了显著的关联,特别是在使用罗马四号标准 (OR 1.59) 的研究中.
- 根据诊断标准 (罗马II,III,IV) 的子组分析显示了显著的差异.
结论:
- 体重过重不太可能是IBS风险的主要驱动因素.
- 未来的研究应该探索纵向数据,体重变化和生活方式因素.
- 需要进行机制研究来理解复杂的IBS-肥胖关系.
相关概念视频
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