孕产妇高脂肪饮食对后代的体质变化 - - 黄类药物的可能有害影响?
Cristina Mihaela Ormindean1, Razvan Ciortea1, Carmen Elena Bucuri1
12nd Department of Obstetrics and Gynecology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Nutrients
|December 17, 2024
概括
怀孕期间的肥胖会影响后代的发育,高脂肪饮食会增加后代的大小. 肥胖母亲的黄类补充剂可能会减少后代的尺寸,但潜在的不良影响需要进一步调查.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 肥胖是与代谢综合征相关的日益严重的公共卫生问题.
- 脂肪组织作为内分泌器官起作用,分泌adipokines,这对生理调节至关重要.
研究的目的:
- 通过动物模型,研究孕期和后代发育对孕产妇肥胖和阿迪波金的影响.
- 评估抗氧化剂和黄类药物对这些由肥胖引起的变化的影响.
主要方法:
- 维斯塔尔白性大鼠被分为控制组 (5%的脂质饮食) 和高脂肪饮食 (HFD,65%的脂质) 组.
- 补充Detralex,Sel-E-Vit和Rutin (抗氧化剂/黄类药物) 给HFD亚组进行了治疗.
- 分析了阿迪波金水平 (莱普丁,维斯法丁),后代人体测量和大脑组织变化.
主要成果:
- 在怀孕的老鼠中,HFD显著增加了体重和腹部脂肪.
- 瘦素水平升高,而视法丁水平降低在HFD养的母亲.
- 来自HFD母亲的后代表现出更高的体重,大脑重量和整体更大的尺寸.
- 在HFD组中补充黄类药物导致后代尺寸较小,与仅使用HFD和对照组相比.
结论:
- 孕产妇肥胖会影响孕期和后代的发育,这与现有知识相一致.
- 黄化合物可能对怀孕和后代发育产生不良影响,需要进一步研究其妊娠风险和益处.
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