肠道微生物群调节Fgf21表达和食诱导的代谢表现型
Xinyi Wei1, Yunxu Lu1, Shangyu Hong1
1State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.
Nutrients
|December 17, 2024
概括
素饮食 (KD) 通过改变肠道微生物群,从而影响体重和葡萄糖,这种微生物群调节FGF21 (纤维细胞生长因子21) 的表达. 这揭示了KD的关键途径.
科学领域:
- 代谢研究的研究.
- 微生物组科学 微生物组科学
- 内分泌学 在内分泌学.
背景情况:
- 素饮食 (KD) 已因其在控制肥胖和糖尿病方面的有效性而得到认可.
- 然而,精确的分子机制,特别是肠道微生物群的作用,仍然不完全理解.
研究的目的:
- 阐明肠道微生物群和FGF21在介导KD代谢作用中的作用.
- 调查参与KD诱导的代谢改善的信号通路.
主要方法:
- 利用抗生素治疗来耗尽小鼠的肠道微生物群.
- 使用Fgf21缺乏的小鼠来评估FGF21的作用.
- 分析了血清氨酸水平和肝脏Fgf21表达.
主要成果:
- 肠道微生物群对于KD诱导的体重减轻和葡萄糖代谢改善至关重要.
- 该KD通过肠道微生物群改变血清氨酸水平,通过GCN2-eIF2α-ATF5通路调节肝脏Fgf21表达.
- 氨酸补充剂抵消了FGF21的升高,降低了体重并改善了葡萄糖代谢.
结论:
- 建立了一个连接KD,肠道微生物群和FGF21表达的调节网络.
- 确定GCN2-eIF2α-ATF5信号通路对于调解KD的代谢益处至关重要.
- 这些发现为开发有针对性的疗法提供了基础,以提高KD的疗效.
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