饮食与类风湿关节炎风险之间的剂量反应关联:对前性队列研究的元分析
Yuanyuan Dong1, Darren C Greenwood2, James Webster3
1Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.
Nutrients
|December 17, 2024
概括
适度饮酒,水果和谷物摄入量可能会降低类风湿性关节炎 (RA) 的风险. 相反,饮用茶和咖啡可能会增加RA风险. 优化饮食可以帮助缓解RA的发展.
科学领域:
- 风湿病学和营养流行病学.
- 系统性审查和元分析
背景情况:
- 类风湿性关节炎 (RA) 是一种具有复杂病因的慢性自身免疫性疾病.
- 饮食因素越来越多地被认为是RA风险和发展的潜在调节者.
研究的目的:
- 系统地审查和定量总结各种饮食因素与患类风湿性关节炎 (RA) 风险之间的联系.
- 进行剂量反应分析,以了解特定的饮食暴露与RA发病率之间的定量关系.
主要方法:
- 2000年至2024年间发表的前性队列研究的系统审查和元分析.
- 包括30项研究,近300万参与者,超过9000个RA病例.
- 使用线性和非线性剂量反应分析来评估相对风险 (RR) 和置信区间 (CI).
主要成果:
- 增加总酒精摄入量 (每周2个单位) 与RA风险降低4% (RR 0.96) 相关.
- 较高的水果 (每天80克) 和谷物 (每天30克) 摄入量显示RA风险降低 (RR分别为0.95和0.97).
- 茶饮 (每杯/天) 与4%的风险增加有关 (RR 1.04),而咖啡显示出非线性关联.
结论:
- 适度饮酒,更多的水果和谷物摄入量与风湿性关节炎风险降低有关.
- 饮用茶和咖啡可能与RA风险增加有关.
- 专注于特定食物成分的饮食修改可能提供RA风险降低策略,并得到中等确定性证据的支持.
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