不适当的饮食会通过腹部肥胖加剧与代谢功能障碍相关的脂肪性肝病
Minghui Xiang1, Xiaoli Tian2,3, Hui Wang4
1National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Nutrients
|December 17, 2024
概括
能量,碳水化合物或加工食品含量高的不健康饮食通过腹部肥胖导致代谢功能障碍相关的脂肪性肝病 (MASLD). 饮食改变可以改善这两种情况.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与代谢功能障碍有关,腹部肥胖 (AO) 是一个关键因素.
- 饮食习惯显著影响AO的发展,影响肝脏健康.
研究的目的:
- 通过AO识别导致MASLD的饮食因素.
- 阐明连接饮食,AO和MASLD进展的生物机制.
主要方法:
- 对影响AO的饮食因素的元分析进行系统审查.
- 关于饮食-AO-MASLD机制的PubMed索引研究的叙事综述.
主要成果:
- 不适当的饮食 (高能量,碳水化合物,果糖,UPF) 促进MASLD和AO.
- 机制包括增强的新型脂质合成,胰岛素抵抗,肠肝功能障碍和炎症.
- AO通过增加的自由脂肪酸,氧化应激和炎症加剧MASLD.
结论:
- 针对不适当的饮食模式的饮食干预可以改善MASLD和AO.
- 了解AO在MASLD进展中的作用对于治疗指南至关重要.
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