约约饮食和抗性粉对胃肠道形态的有害影响
Kate Phuong-Nguyen1,2, Malik Mahmood2, Leni Rivera1,2
1School of Medicine, Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC 3220, Australia.
Nutrients
|December 17, 2024
概括
约约饮食在小鼠中恶化了肠道损伤. 耐性粉 (RS) 补充剂在高脂肪和约约饮食中减少了损伤,但在控制饮食中增加了炎症.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 肥胖问题研究研究
背景情况:
- 肥胖与肠道结构损伤有关.
- 约约饮食 (循环减肥/恢复体重) 在肥胖中很常见.
- 关于节食对肠道结构影响的数据有限.
研究的目的:
- 调查约约饮食对胃肠道结构的影响.
- 确定耐性粉 (RS) 是否减轻与肥胖相关的肠道损伤.
主要方法:
- 小鼠接受了对照,高脂肪 (HF),yoyo或耐性粉 (RS) 的饮食20周.
- 评估结肠炎症,粘膜损伤和上皮屏障完整性.
- 小肠和大肠的组织学评估.
主要成果:
- 约约饮食增加了结肠炎症和粘膜损伤与持续的HF饮食相比.
- 在HF和yoyo饮食中,RS减少了粘膜损伤.
- 对照饮食中的RS增加了炎症,密室长度和杯状细胞密度.
结论:
- 约约饮食会加剧肠道损伤.
- 在没有高脂肪养等饮食挑战的情况下,高RS摄入量可能是有害的.
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