与人类相关的肠道微生物群的组成确定了IL-10 -/-小鼠中的3-DF和3-HF抗结肠炎活性
Jose Haro-Reyes1, Jayaprakash Kanijam Raghupathi1,2, Lavanya Reddivari1
1Department of Food Science, Purdue University, West Lafayette, IN 47907, USA.
Nutrients
|December 17, 2024
概括
饮食中所含的安托西亚宁 (3-HF) 和叶 (3-DF) 具有抗结肠病作用,但它们的有效性取决于接受者的肠道微生物群组成. 健康的人体肠道细菌会影响这些黄胺对性结肠炎模型的影响.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 肠道失调和肠道屏障破坏是性结肠炎的关键因素.
- 黄类药物被探索为潜在的治疗方法,但它们与人类肠道微生物群的相互作用尚不清楚.
- 研究经常使用特定于小鼠的微生物群,限制了对人类相关影响的洞察力.
研究的目的:
- 调查健康的人类肠道微生物群对抗胆固醇素 (3-HF) 和草 (3-DF) 抗结肠炎活性的影响.
- 评估不同的人类肠道微生物组成如何调节富含黄胺的饮食对炎症性肠病模型的影响.
主要方法:
- 使用了对性结肠炎的介质素 (IL) -10 -/-小鼠模型.
- 接种了来自三个健康捐赠者的人类肠道细菌的免疫小鼠.
- 给了四种饮食:一种纯化饮食和三个饮食,补充了表达3-DFs,3-HFs或两者的近同位素玉米线.
主要成果:
- 富含黄胺的饮食并没有普遍改变炎症标志物,微生物群多样性或代谢物.
- 含有反素 (3-HFs) 的饮食表明改善了肠道屏障功能.
- 当基于捐赠者的特定微生物群分析数据时,显著的饮食效应出现了,3-HFs显示出比3-DFs更大的益处.
结论:
- 3-DF和3-HF及其代谢物的抗结肠病疗效取决于接受者的肠道微生物组成.
- 人体肠道微生物群在性结肠炎中调解食黄类药物的治疗作用方面发挥着至关重要的作用.
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