通过利用HME和3D打印技术用水友性聚合物形成无形固体分散物来提高溶解度和开发个性化的伊特拉科纳剂量
Lianghao Huang1,2, Jingjing Guo1,2, Yusen Li1,2
1Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Polymers
|December 17, 2024
概括
这项研究使用无形固体分散物 (ASD) 与聚合物增强了伊特拉科纳 (ITZ) 的溶解性和生物可用性. 热挤出和3D打印实现了个性化的可编程药物释放片.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 伊特拉科纳 (ITZ) 是一种广泛的抗真菌药物,由于溶解度低,其口服生物利用性较差.
- 与剂量相关的不良影响也是传统ITZ配方的一个问题.
- 开发新型配方以提高ITZ溶解度并实现控制释放至关重要.
研究的目的:
- 提高伊特拉可纳 (ITZ) 的可溶性和溶解率.
- 使用先进的制造技术开发个性化和可编程释放ITZ平板电脑.
- 探索无形固体分散 (ASD) 和3D打印用于药物输送的潜力.
主要方法:
- 五种不同的聚合物被评估为ITZ的水溶性载体.
- 热挤出 (HME) 用于创建ITZ-聚合物混合物和纤维.
- 描述涉及DSC,PXRD,PLM和体外药物释放研究;用于平板制造,3D打印.
主要成果:
- ITZ成功地分散在聚合物中,形成ASD,显著提高了溶解度和溶解率.
- Soluplus®被确定为通过HME创建ITZ载荷纤维的最佳聚合物.
- 在体外释放药物的研究表明,ITZ释放可以通过调整3D打印结构来精确控制.
结论:
- HME和3D打印的结合是开发个性化和精确控制的ITZ药物递送系统的一个有前途的战略.
- 这种方法有效地解决了伊特拉可纳的溶解性和生物可用性挑战.
- 开发的技术为量身定制的药物剂量提供了一条途径,以满足个体患者的需求.
相关概念视频
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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
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01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
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01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
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01:27Factors Influencing Drug Absorption: Drug Dissolution
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01:22Factors Influencing Drug Absorption: Physicochemical Parameters
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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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