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Updated: Jun 4, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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古代和最近的NOTCH2基因变异之间的体质重组与慢性淋巴细胞白血病中NOTCH2功能增益表型有关

Rainer Hubmann1,2,3, Martin Hilgarth1, Tamara Löwenstern4

  • 1Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.

International journal of molecular sciences
|December 17, 2024
PubMed
概括

在慢性淋巴细胞白血病 (CLL) 中,构成性活跃的NOTCH2信号与被删除的mRNA序列有关. 遗传的NOTCH2变异体质重组,导致异常拼接和NOTCH2功能增长,可能解释CLLL.

关键词:
在 CLL CLL 中.在NOTCH2中.进化 演化 演化 演化 演化 演化 演化 演化功能收益的功能收益.单质类型的单质类型身体复合的体质复合.

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