DNA甲基化变化和表型适应诱导了在8848米的重复极端高度暴露
Shixuan Zhang1,2, La Yang1, Zhuoma Duoji1
1High Altitude Health Science Research Centre of Tibet University, Tibet University, 10 East Zangda Road, Lhasa 850000, China.
International journal of molecular sciences
|December 17, 2024
概括
在高海拔地区重复的极端环境训练 (RET) 会导致持久的表观遗传变化. 增加RET暴露强化了DNA甲基化和生理特征之间的联系,增强了适应能力.
科学领域:
- 表观遗传学和环境适应
- 高海拔地区的生理学
- 基因组学和现象学
背景情况:
- 众所周知,重复的极端环境训练 (RET) 可以提高人类的适应能力.
- 环境暴露可以诱导持久的表观遗传修饰,特别是DNA甲基化.
- 高海拔暴露具有显著的环境压力因素,影响生理适应.
研究的目的:
- 调查重复高空暴露与表观遗传修饰之间的相关性.
- 为了确定受RET.增加水平影响的特定CpG位点和表型.
- 探索RET对表型和表观遗传相互作用网络的强度的影响.
主要方法:
- 分析了来自高海拔地区的64名参与者的741,489个CpG位点和39个表型.
- 利用贝叶斯因果网络和相互作用网络来建模表型-CpG关系.
- 使用公开的AltitudeOmics数据集 (GEO) 验证已识别的CpG网站.
主要成果:
- 在13个CpG位点和15个与RET暴露相关的表型中发现了显著的变化.
- 观察到系统血压 (SP),血小板计数 (PLT) 和中性粒细胞计数 (NEUT) 的网络强度增加,RET.
- 验证了六个与低氧相关的CpG位点和六个与PLT和红细胞分布宽度标准偏差 (RDW.SD) 相关联的CpG位点.
结论:
- 增加RET暴露增强了表型和CpG位点之间的相互作用.
- 由RET引起的极端适应状态似乎改变了甲基化模式.
- 这些表观遗传变化与关键的生理现象类型 (如PLT,RDW,SD和NEUT) 共同演变.
相关概念视频
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
Phase II Reactions: Methylation Reactions
132
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
132
Genomic Imprinting and Inheritance
33.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
33.2K
Inheritance of Chromatin Structures
6.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K


