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Updated: Jun 4, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
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Published on: April 23, 2016

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LINE-1诱导的逆转换影响早期植入前胚胎DNA完整性和多能性

Prodromos Sakaloglou1, Leandros Lazaros1,2, Ioanna Bouba1

  • 1Laboratory of Medical Genetics and Human Reproduction, School of Health Sciences, Faculty of Medicine, University of Ioannina, 451 10 Ioannina, Greece.

International journal of molecular sciences
|December 17, 2024
PubMed
概括

在人类胚胎中LINE-1逆转移体的过度表达导致DNA损伤和发育障碍. 这种异常的反元素活性对多能因子表达和胚胎活力产生了负面影响.

关键词:
通过DNA甲基化.双链 DNA 断裂,导致双链 DNA 断裂多能性因素是多能性的因素.植入前胚胎的胚胎发育追溯元件的使用

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