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Updated: Jun 22, 2026

Engineering and Evolution of Synthetic Adeno-Associated Virus AAV Gene Therapy Vectors via DNA Family Shuffling
21:55

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Published on: April 2, 2012

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在S/MAR序列的活体选择有利于AAV在分裂细胞中的环节维护

Andrea Llanos-Ardaiz1,2, Aquilino Lantero1, Leire Neri1

  • 1Vivet Therapeutics S.L., 31008 Pamplona, Spain.

International journal of molecular sciences
|December 17, 2024
PubMed
概括

将支架/矩阵附着区域 (S/MAR) 添加到腺相关病毒 (AAV) 载体中,可以改善分裂细胞中的基因组维护. 然而,S/MARs可以降低基因表达,这个问题有可能通过无意中介衰变 (NMD) 抑制序列来解决,以获得更好的基因疗法.

关键词:
在 AAV AAV AAV 中.这是一个NMD.这是S/MAR.这是一种插曲性维护.基因治疗的基因疗法肝脏 肝脏 肝脏 肝脏 肝脏 肝脏复制复制复制复制复制复制复制

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