肥胖的代谢标志和与代谢功能障碍相关的脂肪性肝病
Diren Beyoğlu1, Yury V Popov2, Jeffrey R Idle1
1Department of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.
International journal of molecular sciences
|December 17, 2024
概括
研究人员通过分析90项研究,确定了肥胖和代谢功能障碍相关的脂肪性肝病 (MASLD) 的关键代谢特征或标志. 这些发现将肥胖与肥胖联系起来.
科学领域:
- 代谢学 代谢学 代谢学
- 肝脏疾病研究 肝脏疾病研究
- 肥胖研究 肥胖研究
背景情况:
- 肥胖和与代谢功能障碍相关的脂肪性肝病 (MASLD) 共享复杂的代谢基础.
- 了解这些代谢联系对于开发有效疗法至关重要.
- 以前的研究已经探索了代谢概况,但需要一个整体的观点.
研究的目的:
- 定义肥胖和MASLD的综合代谢特征.
- 在各种实验和临床研究中确定共识生物标志物.
- 阐明肥胖在MASLD病变发生过程中的代谢作用.
主要方法:
- 90个代谢学研究的系统综述和元分析.
- 分析了来自小鼠,老鼠,仓鼠,牛,,斑马鱼和人类的代谢数据.
- 识别跨物种和研究类型的共识生物标志物组.
主要成果:
- 确定了六种肥胖的代谢特征,包括氨基酸,能量代谢产物,肠道微生物群代谢产物,乙卡尼丁和溶酸胆.
- 确定了MASLD的五个代谢特征,包括能量代谢物,氨基酸,脂肪酸和胆汁酸.
- 特定的代谢物升高 (例如,胆固醇,脂肪酸,VLDL/LDL,胆酸,脂胆) 在所有物种中对于肥胖和MASLD是常见的.
结论:
- 代谢特征为了解肥胖在MASLD中的作用提供了一个框架.
- 这些特征可以指导机械学研究疾病的发病因子.
- 已识别的生物标志物对于开发用于MASLD的新型代谢物启发疗法至关重要.
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