肠道微生物群-微RNA相互作用和肥胖病理生理学:综合研究的系统审查
Hushyar Azari1, Megan George1, Kembra Albracht-Schulte1
1Department of Kinesiology and Sport Management and Obesity Research Institute, Texas Tech University, Lubbock, TX 79409, USA.
International journal of molecular sciences
|December 17, 2024
概括
本综述探讨了肠道微生物群和微RNA (miRNAs) 如何相互作用以影响肥胖. 这些相互作用影响炎症和胰岛素信号传导等关键途径,为肥胖提供潜在的治疗点.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 代谢过程中的代谢.
背景情况:
- 肥胖是全球死亡和残疾的主要原因之一.
- 与肥胖相关的并发症给社会带来了巨大的负担.
- 了解导致肥胖的分子机制对于开发有效的治疗方法至关重要.
研究的目的:
- 在肥胖的背景下,审查肠道微生物群和微RNA (miRNAs) 之间的复杂相互作用.
- 总结一下这些相互作用如何影响与肥胖相关的病理途径.
- 确定肥胖及其并发性疾病的潜在治疗点.
主要方法:
- 在主要科学数据库 (PubMed,科学网,Scopus,Science Direct) 的系统文献搜索.
- 根据预先定义的标准,包括八项符合条件的研究 (两个人,六个动物受试者).
- 在肥胖中分析了特定miRNAs和肠道微生物种群之间报告的关联.
主要成果:
- 肥胖症中的肠道微生物群和miRNA相互作用是多样化的,可以是特定于组织的.
- 这些相互作用调节了与肥胖相关的关键途径:炎症,氧化应激,胰岛素信号,肠道透性和脂质生成.
- 具体例子包括脂肪组织miRNA-378a-3p/5p和*Bifidobacterium*/*Akkermansia*,肝脏miRNA-34a和*Firmicutes*,以及miRNA-122-5p/miRNA-375和*Bacteroides*之间的关联.
结论:
- 微RNA和肠道微生物群之间的相互作用是肥胖研究的一个复杂但有前途的领域.
- 准miRNA-微生物群相关途径可能为肥胖及其并发症提供新的治疗策略.
- 需要进一步的研究来阐明这些复杂的机制,并将发现转化为临床应用.
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